Does the DSCAM gene (Down Syndrome Cell Adhesion Molecule) fit into this picture at all? This gene is very unusual, as it gets spliced 38,000 different ways wit

Does the DSCAM gene (Down Syndrome Cell Adhesion Molecule) fit into this picture at all? This gene is very unusual, as it gets spliced 38,000 different ways with different variants in different neurons, allowing the brain to get wired up correctly. (It's like being able to give neurons in the developing brain labels to keep track of where they go.) Since this gene is in the part of chromosome 21 that causes Down Syndrome, it seems to have an important role in Down Syndrome. But I don't see any connection between it and the current paper. Any experts who can explain more? When I read about this gene a few years ago, it seemed like a key to explaining how the brain is formed, but I haven't seen much about it since then.