3 ms·

So what would be required for the mice to have something sufficiently Down's-like? They didn't shrink the brains with toxins or anything, that shrinkage was a n

So what would be required for the mice to have something sufficiently Down's-like? They didn't shrink the brains with toxins or anything, that shrinkage was a natural consequence of duplication of genes, just as it is in human DS.

epo 13y ago
Some genes, not all of them. The experiment was about brain shrinkage, not Down's syndrome.
- vilhelm_s 13y ago
  The mice are made specifically as an animal model of Down syndrome. See http://dmm.biologists.org/content/4/5/596.full http://dmm.biologists.org/content/4/5/596.full