This problem never came up for me. I am an Emacs user with both keys either side of Space bar mapped to Ctrl. And I use Ctrl with either hand using my thumbs

This problem never came up for me. I am an Emacs user with both keys either side of Space bar mapped to Ctrl. And I use Ctrl with either hand using my thumbs bent inwards (or sometimes with my palms). I also try to use mouse minimally.