I try to stick to around 200 people (anymore and I have a hard time keeping up). While a big chunk of who I follow is coworkers or people related to my work, th

I try to stick to around 200 people (anymore and I have a hard time keeping up). While a big chunk of who I follow is coworkers or people related to my work, theres also people/accounts like: @pycoders @jessenoller for python related stuff, and @zeeg for python and startup insights (he's behind getsentry.com) @nntaleb @neiltyson for my daily dose of awesome science/math/logic. @wilw @pvbrett @deadmau5 for some celebrity/author/music nerd fixes. @deadmau5 is worth following alone for the pictures of his awesome studio setup. A pretty good tactic i've found is to find someone who's interest's align with your own and see who they are following.