I don't generally do Django, but I don't think it should be a problem. Just a word of warning - if you're going to use a global per-app SMTP connection remember

I don't generally do Django, but I don't think it should be a problem. Just a word of warning - if you're going to use a global per-app SMTP connection remember to wrap it in connstack. The Flask example shows this and it shouldn't be hard to do the same in Django.