mod_python was already considered borderline-obsolete by the time I started seriously working with Python, so I never did much with it and can't speak authorita

mod_python was already considered borderline-obsolete by the time I started seriously working with Python, so I never did much with it and can't speak authoritatively to its particular capabilities, but one advantage some of the "mod_[language]"s had was being able to integrate closely with Apache in ways that otherwise required writing a C module. As I recall from an earlier life, mod_perl was especially powerful in this regard. That said, I don't think I'd use any such server-specific modules today. I'm very fond of the model of something like Apache or nginx as a proxy in front of things like gunicorn or Go's net/http library.