Here are some of my favs: 1) Quicksilver. (free) http://blacktree.com/?quicksilver http://blacktree.com/?quicksilver 2) VLC Media Player. (free) It plays pret

Here are some of my favs: 1) Quicksilver. (free) http://blacktree.com/?quicksilver http://blacktree.com/?quicksilver 2) VLC Media Player. (free) It plays pretty much every type of video file. http://videolan.org/vlc http://videolan.org/vlc 3) Skitch. (free) Essential for quick screenshots, and quick annotations of screenshots. http://plasq.com/skitch http://plasq.com/skitch 4) Tweetie. (free - ad supported - or $20) The best native Mac app for Twitterring. http://atebits.com/tweetie-mac http://atebits.com/tweetie-mac 5) TextMate. (~$54) It's handling of projects, bundles, etc. is excellent. http://macromates.com http://macromates.com 6) HTTP Client. (free) http://ditchnet.org/httpclient/ http://ditchnet.org/httpclient/ 7) OmniGraffle. ($100-$200) Excellent for constructing user flow diagrams. http://www.omnigroup.com/applications/OmniGraffle/ http://www.omnigroup.com/applications/OmniGraffle/ 8) The Hit List. ($50) It's one of the best GTD apps for the Mac. http://www.potionfactory.com/thehitlist/ http://www.potionfactory.com/thehitlist/ 9) TinkerTool. (free) For customizing OS X. http://www.bresink.de/osx/TinkerTool.html http://www.bresink.de/osx/TinkerTool.html 10) Secrets. (free) For easy access to hidden application preferences. http://secrets.blacktree.com/ http://secrets.blacktree.com/ 11) Sequel Pro. (free) For accessing MySQL databases in a nice GUI. http://www.sequelpro.com/ http://www.sequelpro.com/ 12) Fluid. (free) If you have a commonly accessed site, Fluid is great to create a SSB (site-specific browser) for it. I have a Fluid SSB created for railsapi.com, which allows me to easily launch it with Quicksilver and start searching the Rails docs right away. http://fluidapp.com/ http://fluidapp.com/