One of the major downsides to most of the diverted licit opioids is that they're intended primarily for oral use, and hence contain all sorts of things that wil

One of the major downsides to most of the diverted licit opioids is that they're intended primarily for oral use, and hence contain all sorts of things that will do terrible things when injected directly into a vein. Tiny particles of tablet filler & binding usually wash up and get stuck in the lungs, leading to a pneumonia-like condition called Talcosis. Then you have the new "anti-abuse" formulations, which contain specific ingredients designed to be uncrushable, unpleasant if injected, or insoluble/gel-forming to prevent IV use. Given junkie creativity (and suppressed self-preservation instinct), there are various methods of bypassing these obstacles, but in doing so could affect the potency of the extracted remains by a factor of 2-10x. So now you have no idea how much you're dosing, as well as what's still along for the ride. At least heroin dealers would typically only cut with toxic adulterants by negligence, rather than intent. [not an opiate (ab)user, known a few]