I'm surprised that nobody suggested Web.py (http://webpy.org/ http://webpy.org/) by Aaron Swartz. Since you're comfortable with Python, that's the best starting

I'm surprised that nobody suggested Web.py (http://webpy.org/ http://webpy.org/) by Aaron Swartz. Since you're comfortable with Python, that's the best starting point, I guess. If you're ready to give Ruby on more shot, try Sinatra or Ramaze. Both excellent light-weight frameworks.