Well as a commercial pilot all the other replies are right, but I guess you mean also if a 747 pilot could seat at a 380 cockpit and make a manual flight. Obvio

Well as a commercial pilot all the other replies are right, but I guess you mean also if a 747 pilot could seat at a 380 cockpit and make a manual flight. Obviously is not the best idea as there are a lot of differences on the autoflight and all the rest of systems and instruments. It´s not only learning them by the book, is also getting used, and knowing where to look for a speed or for a heading, it takes some weeks to get used. But in short to fly like a Cessna (a visual simple flight around the airport or a manual landing), a competent pilot (not like the ones described at the article) is able to do it reasonably well no matter what kind of airplane. Of course this is not legal or recommended (Some times it is done in simulators if there is some time left in a friend´s session)