Without knowing anything about hdf5 specifically, Vertigo [1] will let you treat a memory-mapped file (or a piece of one) as a normal Clojure data structure, as

Without knowing anything about hdf5 specifically, Vertigo [1] will let you treat a memory-mapped file (or a piece of one) as a normal Clojure data structure, as long as the element types are fixed-layout. [1] https://github.com/ztellman/vertigo https://github.com/ztellman/vertigo