Possible sanity damage - well, if they've got it wrong I'd expect them not to have a functional brain simulation at all. But maybe. I wouldn't be so sure that

Possible sanity damage - well, if they've got it wrong I'd expect them not to have a functional brain simulation at all. But maybe. I wouldn't be so sure that they'd immediately be all that powerful though. Just because you're running on a certain architecture doesn't mean you understand the first thing about it or how to modify it - just think how long it's taking humans to understand and alter neurology. Admittedly they might have a speed advantage, but who knows what they'll use that for - depending on the person and the environment they might spend the next thousand years taking e-heroin, or playing tick tack toe. And, if they really are an insane sorcerer, do you want them to think that you're not going to respect their rights?... Though, this does strike me as a good argument for only running the initial upload on crippled systems - no access to the internet, limited speed, etc.