I haven't read this paper, but I have read the 2007 paper they mention in the article. In that study, the mice were trained in a Morris water maze task. Then, d

I haven't read this paper, but I have read the 2007 paper they mention in the article. In that study, the mice were trained in a Morris water maze task. Then, different groups are tested either immediately, 3 hours later, 24 hours later or 2 weeks later. Some in each group were given a histone deacetylase inhibitor, and they were compared to controls that were not. All these mice were transgenic knockout mice. When put on a diet containing doxycycline, their brains begin to atrophy. (Edit: all the experimental mice were on this diet) I assume this paper uses a similar procedure.