19 ms·
I'm curious as to how they know the mice regained long-term memories...
by TallGuyShort 18y ago
I'm curious as to how they know the mice regained long-term memories...
- gcheong 18y agoI'm guessing by their ability to navigate a maze and how quickly they can do it on subsequent tries.
- a-priori 18y agoI haven't read this paper, but I have read the 2007 paper they mention in the article. In that study, the mice were trained in a Morris water maze task. Then, different groups are tested either immediately, 3 hours later, 24 hours later or 2 weeks later. Some in each group were given a histone deacetylase inhibitor, and they were compared to controls that were not. All these mice were transgenic knockout mice. When put on a diet containing doxycycline, their brains begin to atrophy. (Edit: all the experimental mice were on this diet) I assume this paper uses a similar procedure.