I haven't tried it myself but the mono guys have an article on getting nginx up and running with fastcgi-mono-server2 http://www.mono-project.com/FastCGI_Nginx

I haven't tried it myself but the mono guys have an article on getting nginx up and running with fastcgi-mono-server2 http://www.mono-project.com/FastCGI_Nginx http://www.mono-project.com/FastCGI_Nginx