The difference is that the random mutations are random across the genome while the GM wheat is universally altered in the same way. So, while you might not be

The difference is that the random mutations are random across the genome while the GM wheat is universally altered in the same way. So, while you might not be harmed by the millions of random mutations in the non-GM slice of bread you eat, it's conceivable that if you eat a GM slice of bread where ever single cell has the same mutation your body might not react so favorably.