I could see this being semi-automated to the point where the drones can travel between the home base (there can be special devices to assist the drone with auto

I could see this being semi-automated to the point where the drones can travel between the home base (there can be special devices to assist the drone with automatically landing that you wouldn't have on a home or business) and some radius near the drop location by themselves then you have some human assistance with the final 100 feet or so. This would make it possible to need only 1 operator for a small city, I think. He'll only need to be concerned with landings/near-ground hovering then getting back in the air for the trip back home or to another drop. I'm sure there will be some kind of regulation/standard that will deal with the way drones avoid other drones (and other tall structures) while in the air.