Use pyramid. It's exceptionally well designed. It has very sensible defaults out of the box, but literally everything about the framework is swappable if you ne

Use pyramid. It's exceptionally well designed. It has very sensible defaults out of the box, but literally everything about the framework is swappable if you need it to be. I can't comment on rails, but I spent quite a long time with django before switching to repoze-bfg (pyramid's previous name). In my experience you don't hit the same wall that you tend to with django when you need to step off the the common path.