To me its less about the location, than how you go about running your startup. As Jeff says, working from home and distributed teams help a lot. In my experienc

To me its less about the location, than how you go about running your startup. As Jeff says, working from home and distributed teams help a lot. In my experience that can enable you to maintain a very healthy engagement with your family while still working at founder-desperate levels. For example I picked up the kids from school every day and spent some time with them in the afternoon, which refreshed me to do much more work in the evening. Of course, there will be times when founders need to be on the road a lot. But putting these trips on top of a base of family engagement makes them a lot less painful for all involved.