I would go with Django over web2py. If you're looking for more of a microframework, I would look at Flask. Having built enterprise applications in Rails and Dj

I would go with Django over web2py. If you're looking for more of a microframework, I would look at Flask. Having built enterprise applications in Rails and Django, I would recommend Django over Rails 99.999% of the time. Django is a very homogeneous framework; it's easy to use, learn, deploy, maintain and has built-in ways to do just about anything you'd need to do in a web application. Rails is more like a piece of flypaper, that you trow a bunch of stuff (gems) at and pray they stick. You can't even upload a file in Rails without using a plugin.