Unless I'm missing the point of your argument, it sounds like you're saying that, e.g., computational biology does not benefit from representation as immutable

Unless I'm missing the point of your argument, it sounds like you're saying that, e.g., computational biology does not benefit from representation as immutable data structures. Although I have no experience writing software for modeling cell or biological entity behavior, I strongly suspect that reasoning about the simulation itself by representing its states through immutable data structures, or immutable databases, will lend itself to a better piece of simulation software. If you think I'm wrong about this, I'd appreciate some examples.