I'm not aware of a direct comparison of Perl and PyPy. However, for a paper I co-authored, we put together an experiment with various languages and VMs, using t

I'm not aware of a direct comparison of Perl and PyPy. However, for a paper I co-authored, we put together an experiment with various languages and VMs, using the language shootout plus a few other benchmarks: http://tratt.net/laurie/research/pubs/files/metatracing_vms/ Cross-langauge benchmarks are inevitably synthetic, and synthetic benchmarks can only tell you so much. It's important not to over-interpret them. But they can give you a rough idea of what's going on, at least in some circumstances. If someone wanted to add Perl to the experiment set, I'd gladly accept a patch to the benchmarking suite.