I started out using Octopress but in the end chose to go just plain Jekyll and borrow from Octopress only the things I needed. I'm pretty happy with my decision

I started out using Octopress but in the end chose to go just plain Jekyll and borrow from Octopress only the things I needed. I'm pretty happy with my decision. Ultimately, you just need to look at the feature-set of Octopress and decide if you actually want those things (custom theme, Disqus and GA integration, etc). If you do, great, if not, it's probably going to get in the way more than help.