It depends on complexity. This is my python stack: Simple stuff (API endpoint only, minimal routing, minimal cookie/session related stuff) - Bottle.py Simple

It depends on complexity. This is my python stack: Simple stuff (API endpoint only, minimal routing, minimal cookie/session related stuff) - Bottle.py Simple stuff that needs really high performance squeezed out: Wheezy.web + gevent (this category is new. I invented it as an excuse to play with wheezy.web) Moderately complex stuff (rendering, session, fancy routing): web.py Complex stuff: pyramid. I would rather nerf my projects than go to highly complex web stacks. My Golang stack: Gorilla or plain golang. Frontend: I am not really a fan of frontend rendering, but if I need to, AngularJS is my preferred framework. Database part of the stack: I use postgres for SQL stuff. MySQL is used when there are more people in the team involved. Considering MariaDB for dropin replacement if a team is involved. Still haven't bothered. My preferred document based nosql database is couchdb. Preferred KV store is redis. OS: I used to develop for CentOS but strangely in the past 2 years I have moved on to Ubuntu. Sometimes updates can break things, but I certainly prefer it to the glacial CentOS or Debian