I don't understand why they are saying this is the first time someone is saying that genes, and genetic association, are not sufficient. Eric Schadt has publis

I don't understand why they are saying this is the first time someone is saying that genes, and genetic association, are not sufficient. Eric Schadt has published some great work on network analysis and eQTL (http://www.ncbi.nlm.nih.gov/pubmed/18552845 http://www.ncbi.nlm.nih.gov/pubmed/18552845). Others have argued about the importance of studying copy number variation.