Indeed! And crazier still, you can have two proteins with substantial structural homology, but with entirely different functions and mechanisms. When I worked

Indeed! And crazier still, you can have two proteins with substantial structural homology, but with entirely different functions and mechanisms. When I worked in structural bio, one of my colleagues was studying a protein [complex] that had a prominent structure homologous to a helicase, but no DNA-unwinding activity whatsoever. To this day it's unknown what that structure does. I'm excited to more progress linking structure to function, even if this is very very difficult.