Hi TA, You may already know this but generally it is contraindicated to prescribe antidepressants in bipolar (manic-depressive illness) because of the risk of

Hi TA, You may already know this but generally it is contraindicated to prescribe antidepressants in bipolar (manic-depressive illness) because of the risk of triggering mania. Contra-indicated, but not unknown. Bipolar and depression are, of course, very different illnesses. As an aside, this basic research (binding adenosine receptors) is interestingly at odds with the very interesting drug modafinil which partially works by increasing reuptake/clearing adenosine from the brain, which has been thought to be responsible for its wakefulness promoting and antidepressant effects Thought you would find that interesting