I've had some success with removing specific fonts entirely: font-family: sans-serif; You get Helvetica on Mac, Arial on Windows and various other default f

I've had some success with removing specific fonts entirely: font-family: sans-serif; You get Helvetica on Mac, Arial on Windows and various other default fonts on other platforms. Users can also pick their own font via browser settings. For pixel-perfect alignment, you need to deal with some minor size differences between the fonts, but pixel-perfect design is not really achievable in many designs anyway.