Thanks for saying what you just did. Although my protein structure prediction days are far beyond me, cycles for projects like these are, for the most part, no

Thanks for saying what you just did. Although my protein structure prediction days are far beyond me, cycles for projects like these are, for the most part, not going to result in major scientific advancement. In most cases, they are a proof of concept, but you really can't do any production work using spare home computers. Now research on accelerated hardware, new scale out programming models, better algos is all worth it. I will disagree on the utility of figuring out a structure though and this is based on experience where there was always a dual component to research, which the prediction guiding, for example, site-directed mutagenesis experiments. The computational design is a lot cheaper and can really help guide project direction. And in the long run, there is nothing wrong with just understanding the physics of folding. The problem is we really aren't there yet, but that doesn't mean we should stop