If you use bind-key -n C-f some-tmux-command it'll bind directly to Contrl-f. The -n means no prefix. I don't know how you'd make tmux recognize the Mac's comm

If you use bind-key -n C-f some-tmux-command it'll bind directly to Contrl-f. The -n means no prefix. I don't know how you'd make tmux recognize the Mac's command key though.