7 ms·
My best friend was just put into hospice for metastasized melanoma. He's 35. Where is this stuff? Nothing more useful to add to this comment. Sorry
by jasallen 14y ago
My best friend was just put into hospice for metastasized melanoma. He's 35. Where is this stuff?
Nothing more useful to add to this comment. Sorry
- pcrh 14y agoSorry for your friend. This is the original article: http://www.pnas.org/content/109/17/6662 http://www.pnas.org/content/109/17/6662 You can actually get the antibody yourself, FTA: "The anti-hCD47 (B6H12) hybridoma was obtained from the ATCC" [http://www.lgcstandards-atcc.org/Products/All/HB-9771.aspx http://www.lgcstandards-atcc.org/Products/All/HB-9771.aspx] Purifying it is easy, if you have a lab. However... you can't use that antibody directly in humans, since it is a mouse antibody, which the human immune system will recognize as foreign. So, even if this treatment were to work, it is necessary is to first "humanize" the antibody so it won't be rejected, and then you can see what effect you get in a clinical trial. I imagine this is what the $20mil funding is for. You can find clinical trials for new drugs here: http://clinicaltrials.gov/ http://clinicaltrials.gov/
- wwwtyro 14y agoCan you use this one directly in humans? Both humans and mice are mentioned, and I do not know how to interpret the nomenclature: http://www.biolegend.com/biotin-anti-human-cd47-antibody-3706.html http://www.biolegend.com/biotin-anti-human-cd47-antibody-370...
- pcrh 14y agoThat is a mouse antibody (viz, Isotype: Mouse IgG1, κ) targeted to the human CD47 protein, the same problem exists as for the one mentioned in the above article.