I like the relative simplicity of 960.gs. It does a reset and then has a fairly simple set of glasses for actually do the grid. It also comes w/ a basic typog

I like the relative simplicity of 960.gs. It does a reset and then has a fairly simple set of glasses for actually do the grid. It also comes w/ a basic typography class that I'll overwrite w/ my own base preferences. I find that it saves me A LOT of time when doing sites that fit the grid style, which are most. It's out of the box functionality really shines when you realize you don't need to play around with floats, margins, and other CSS "tricks" to get your CSS layouts working across browsers. The biggest issue I see with 960 vs. Blueprint is that I believe Blueprint will allow you any width you'd like. Resizing 960 probably isn't a huge ordeal but it's not as simple as in Blueprint.