Fats and Carbs don't vary that much regarding satiety. Mostly protein and fiber, as I said. How adipocytes "should" behave depends on circumstances... Insulin

Fats and Carbs don't vary that much regarding satiety. Mostly protein and fiber, as I said. How adipocytes "should" behave depends on circumstances... Insulin resistance is probably more a defensive mechanism against the deleterious effects of overeating. "The flawed thinking, that calories burned by the body is a fixed amount that doesn't vary based on calories consumed, is simply wrong." Who believes that nonsense? Of course we have adaptive mechanisms that regulate energy output (especially NEAT) based on energy intake. The kcal in/out model is very much valid. You just have to account for fluctuating variables in the formula. "The key is that energy expenditures only rise when the calories consumed are not being partitioned for storage. Elevated insulin levels cause storage of fatty acids, and inhibit release of fatty acids from fat cells by triggering them to be bound up into triglyceride molecules." But this does not happen in a vaccum. This does not matter if you undereat. And if you overeat on mostly fat we still have extremely significant mechanisms to store these TAGs independently of insulin : HSL / ASP.