Left handed Android user. hold to talk: left hand operate 1 handed: left hand operate 2 handed: right hand holds, left hand drives stored in right front poc

Left handed Android user. hold to talk: left hand operate 1 handed: left hand operate 2 handed: right hand holds, left hand drives stored in right front pocket. (keys and money clip incumbent in left front) I wonder if mouse use in the right hand has any impact on left hand use?