Wrists - not at all. I have the old model of the Lifespan Treadmill desk - check here for a photo: http://www.amazon.com/LifeSpan-TR1200-DT-Treadmill-Desk-Model

Wrists - not at all. I have the old model of the Lifespan Treadmill desk - check here for a photo: http://www.amazon.com/LifeSpan-TR1200-DT-Treadmill-Desk-Model/dp/B006M2PJV0/ref=sr_1_1?ie=UTF8&qid=1359565421&sr=8-1&keywords=tr1200dt http://www.amazon.com/LifeSpan-TR1200-DT-Treadmill-Desk-Mode... I rest my elbows on the pad on the front, with my keyboard about a foot forward on the desk. No matter my body's movement, my arms are stable and anchored. With respect to eyesight, there is mild movement but I don't find it bothersome or difficult. First, it is very mild - maybe an inch or two between steps. Second, it's more of a front-back movement than up-down (remember, this is a walking treadmill, not a running treadmill), so I find it does not at affect my field of vision nor what my eyes are focused on.