Does she have health insurance? If so, have her talk to her PCP about antidepressants. You can be the best spouse in the world, but sometimes you're fighting a

Does she have health insurance? If so, have her talk to her PCP about antidepressants. You can be the best spouse in the world, but sometimes you're fighting a chemical equation that will render your best efforts in vain. (It's not your fault!) I know there's a lot of stigma around antidepressants, but I was chronically suicidal for years and finally having access to health care (and antidepressants) was literally the only thing that made a significant change and finally stopped a rather overwhelming amount of constant suffering. Offer to go with her if she's feeling anxious about a doctor visit. (You didn't mention if she had anxiety problems, but depression and anxiety often occur together.)