this won't be seen anymore, euro-timezone for the win, but anyway: 1., google did produce google search. i don't think there is a more important product in the

this won't be seen anymore, euro-timezone for the win, but anyway: 1., google did produce google search. i don't think there is a more important product in the last 20 years when it comes to the knowledge of the world. 2., apple's iphone is being used as a platform for health services (to stay in your health example). there are health startups targeting iOS, big pharma as well - patient adherence programs, even diabetes hardware, just look: http://www.bgstar.com/web/ibgstar http://www.bgstar.com/web/ibgstar 3., facebook, twitter facilitate human interaction. see the arab spring, it was not facebook specifically, but the network effect within it helped the people in egypt, etc. to post, share, discuss. 4., even small examples count, just look at BingoCardCreator with it's HN fame. it targets teachers, do you need something more nobler, grandiose than that?