I can see the advantage to expanding the pool of potential building blocks with which we can make biomolecules. I can see how this would enable novel biomolecu

I can see the advantage to expanding the pool of potential building blocks with which we can make biomolecules. I can see how this would enable novel biomolecules to be made. I can see why you would need custom ribosomes to build these new biomolecules. I can't see why you need to do this in artificial lifeforms rather than E.coli. If it is possible to do this in E.coli then the hard task, modifying the ribosomes to support manufacturing these novel biomolecules, is still to come.