Chrome does integrate with this functionality. Also, some apps doesn't even need to integrate, as the OS will override and auto-apply files for some blackliste

Chrome does integrate with this functionality. Also, some apps doesn't even need to integrate, as the OS will override and auto-apply files for some blacklisted apps, see /System/Library/CoreServices/CoreTypes.bundle/Contents/Resources/Exceptions.plist for LSFileQuarantineEnabled