Agreed that Radio Lab and Stack Overflow are the best ones, but I would add Venture Voice to that list too. Google Developer Podcast is occasionally interesting

Agreed that Radio Lab and Stack Overflow are the best ones, but I would add Venture Voice to that list too. Google Developer Podcast is occasionally interesting. Hanselminutes may have a few good episodes, but is usually too Microsofty. There are also some nice language podcasts out there, at least Learn Thai Podcast and JapanesePod101 are quite good. All of these can be found on iTunes.