I guess it would be the standard constraints for anything over a network, particularly a WAN: latency and throughput. If you have a lot of small queries latenc

I guess it would be the standard constraints for anything over a network, particularly a WAN: latency and throughput. If you have a lot of small queries latency might kill you, and if you have large result sets throughput might kill you. (Also, I don't know how safe the mysql connection is outside a firewalled LAN. Maybe that's not an issue.)