How about sandbox escape + cyber security collapse + 50 (or 500) deadly and highly contagious novel pathogens with long incubation period that humans can't poss

How about sandbox escape + cyber security collapse + 50 (or 500) deadly and highly contagious novel pathogens with long incubation period that humans can't possibly roll out vaccines for simultaneously. At least the first two should seem like a near-term worry after the past five months.