3 ms·

I'm just asking if you've ever used one. I don't want to assume, but if you've used one, you would understand the benefits are far greater than weight loss.

faangguyindia 1mo ago
[flagged]
- tomhow 1mo ago
  Please don't harangue people about exercise and diet on HN. Everyone has heard it countless times here and elsewhere. Obviously, many people find that approach doesn't (easily) work. Yes, it's well known GLP-1s can have negative effects. Many people still find them beneficial anyway, and many people take measures to address the negative effects. None of this is simple or easy, so please stop making it out like it should be a simple or easy decision for people to just do as you suggest. In HN guidelines terms, these sections are relevant: Be kind. Don't be snarky. Converse curiously; don't cross-examine. Edit out swipes. Comments should get more thoughtful and substantive, not less, as a topic gets more divisive. Eschew flamebait. Avoid generic tangents. Omit internet tropes. Please don't post shallow dismissals, especially of other people's work. A good critical comment teaches us something. https://news.ycombinator.com/newsguidelines.html https://news.ycombinator.com/newsguidelines.html
  - faangguyindia 1mo ago
    Pushing drugs to people which can crash your appetite is much more dangerous than promoting exercise and diet to sedentary people. Getting 20 kg overweight only requires a 100 kcal surplus over a period of 4 years. That's not proof that diet and exercise are not working, and it doesn't prove you need GLP-1s to resist an extra 100 kcal a day. Two slices of bread have 130 kcal for comparison.
    - tomhow 1mo ago
      It’s this repetition of caloric balance dogma that’s most unhelpful and unwelcome here. If if was that simple, everyone would already have done it. Appetite and metabolism are not that simple and continuing to insist that they are serves only to alienate anyone who isn’t already committed to that worldview. Nobody disputes that there are risks that need to be understood and addressed.
      - faangguyindia 1mo ago
        > Appetite and metabolism are not that simple and continuing to insist that they are serves only to alienate anyone Funny enough, you want to argue with people who have done some real work in this field and produced results in thousands of people? But you do not provide any refutation. I think i know quite a lot about this already: https://macrocodex.app/knowledge/macrocodex/smart-calorie-burn-v2/ https://macrocodex.app/knowledge/macrocodex/smart-calorie-bu... We've written this algorithm; it factors all the math and current research. Let me know if you have any evidence to refute this, or if you have any paper or mechanism we do not already factor in. Here's our claim: "Guaranteed results within 2-4 weeks of using macrocodex, people will see weight loss or weight gain depending on what they want." And we do not even have a paywall, ads, or upsells in our proof-of-concept app, which implements this algorithm. Other than this we've people already seeing benefit from our approach, just because you failed to apply deficit doesn't mean "calorie deficit" doesn't work or "calorie balance" is flawed, you simply fail at figuring out how much you actually burn Also, we are challenge any organization to perform trial: Macrocodex vs. GLP-1 drugs: on average overweight and obese individuals Our data demonstrate Macrocodex will come out ahead of GLP-1 drugs.
        tomhow 1mo ago
        Now that I've looked through your comment history, I see that you've been using HN for self-promotion, which is also against the guidelines. If you have material consisting of novel research that the audience will find intellectually gratifying, you're welcome to share it as a standalone post. It's not good community participation to hijack other people's launch posts with this kind of antagonistic commentary when you have a competing agenda. Edit: removed initial mistaken accusation of failing to disclose competing product.
bertylicious 1mo ago
What exactly are these benefits beyond weight loss?

faangguyindia 1mo ago

[flagged]

tomhow 1mo ago
Please don't harangue people about exercise and diet on HN. Everyone has heard it countless times here and elsewhere. Obviously, many people find that approach doesn't (easily) work. Yes, it's well known GLP-1s can have negative effects. Many people still find them beneficial anyway, and many people take measures to address the negative effects. None of this is simple or easy, so please stop making it out like it should be a simple or easy decision for people to just do as you suggest. In HN guidelines terms, these sections are relevant: Be kind. Don't be snarky. Converse curiously; don't cross-examine. Edit out swipes. Comments should get more thoughtful and substantive, not less, as a topic gets more divisive. Eschew flamebait. Avoid generic tangents. Omit internet tropes. Please don't post shallow dismissals, especially of other people's work. A good critical comment teaches us something. https://news.ycombinator.com/newsguidelines.html https://news.ycombinator.com/newsguidelines.html
- faangguyindia 1mo ago
  Pushing drugs to people which can crash your appetite is much more dangerous than promoting exercise and diet to sedentary people. Getting 20 kg overweight only requires a 100 kcal surplus over a period of 4 years. That's not proof that diet and exercise are not working, and it doesn't prove you need GLP-1s to resist an extra 100 kcal a day. Two slices of bread have 130 kcal for comparison.
  - tomhow 1mo ago
    It’s this repetition of caloric balance dogma that’s most unhelpful and unwelcome here. If if was that simple, everyone would already have done it. Appetite and metabolism are not that simple and continuing to insist that they are serves only to alienate anyone who isn’t already committed to that worldview. Nobody disputes that there are risks that need to be understood and addressed.
    - faangguyindia 1mo ago
      > Appetite and metabolism are not that simple and continuing to insist that they are serves only to alienate anyone Funny enough, you want to argue with people who have done some real work in this field and produced results in thousands of people? But you do not provide any refutation. I think i know quite a lot about this already: https://macrocodex.app/knowledge/macrocodex/smart-calorie-burn-v2/ https://macrocodex.app/knowledge/macrocodex/smart-calorie-bu... We've written this algorithm; it factors all the math and current research. Let me know if you have any evidence to refute this, or if you have any paper or mechanism we do not already factor in. Here's our claim: "Guaranteed results within 2-4 weeks of using macrocodex, people will see weight loss or weight gain depending on what they want." And we do not even have a paywall, ads, or upsells in our proof-of-concept app, which implements this algorithm. Other than this we've people already seeing benefit from our approach, just because you failed to apply deficit doesn't mean "calorie deficit" doesn't work or "calorie balance" is flawed, you simply fail at figuring out how much you actually burn Also, we are challenge any organization to perform trial: Macrocodex vs. GLP-1 drugs: on average overweight and obese individuals Our data demonstrate Macrocodex will come out ahead of GLP-1 drugs.
      - tomhow 1mo ago
        Now that I've looked through your comment history, I see that you've been using HN for self-promotion, which is also against the guidelines. If you have material consisting of novel research that the audience will find intellectually gratifying, you're welcome to share it as a standalone post. It's not good community participation to hijack other people's launch posts with this kind of antagonistic commentary when you have a competing agenda. Edit: removed initial mistaken accusation of failing to disclose competing product.

bertylicious 1mo ago

What exactly are these benefits beyond weight loss?