3 ms·

Though this article concentrates on the SSRIs, other meds like the SNRIs can have a similar or even worse withdrawal effect. We didn't call it "Side Effexor" fo

Though this article concentrates on the SSRIs, other meds like the SNRIs can have a similar or even worse withdrawal effect. We didn't call it "Side Effexor" for nothing. People legitimately need these drugs, including in the short term. The problem for acute stressors once they resolve is how to get them back off.

Paracompact 1mo ago
> Though this article concentrates on the SSRIs, other meds like the SNRIs can have a similar or even worse withdrawal effect. And don't even get me started on tricyclics or MAOIs... no, seriously, don't get me started on them! The current generation of first-line antidepressants (SSRIs/SNRIs) might as well be free compared to the old school crazy pills.
- SV_BubbleTime 1mo ago
  > school crazy Yep, that’s how I associate SSRIs.
- sheepscreek 1mo ago
  Much of medicine (especially mental health related) is rather primitive. We are literally reverse engineering discoveries that seem to work on some other animals, and then figuring out how (to the best of our limited ability). I liken SSRIs to carpet bombing - also their mechanism to increase seratonin in the brain is by making something else not use it (reuptake inhibition). We’re guessing that other thing isn’t a big deal. But who knows. Serotonin is produced in the gut and it controls melatonin, which controls our sleep. It’s all connected in a bizarre way.
  - matheusmoreira 1mo ago
    > I liken SSRIs to carpet bombing It's like inserting objects into the body's event loop and hoping it produces the desired effects as it circulates, only to find that everything reacts to the event, not just the parts we want. https://news.ycombinator.com/item?id=37029912 https://news.ycombinator.com/item?id=37029912
- KurSix 1mo ago
  It's probably less "modern antidepressants are uniquely bad" and more "we got much better at starting people on safer drugs than we did at figuring out how to stop them"
deleted 1mo ago
[deleted]
KurSix 1mo ago
For something prescribed to get someone through a temporary crisis, "how and when do we get you back off this safely?" should probably be discussed at the beginning, not years later when the patient decides to stop.
- bcjdjsndon 1mo ago
  [flagged]
  - probably_wrong 1mo ago
    If a fireman is trying to stop a house fire and suddenly they catch fire themselves, no one would argue that they need to focus on the house fire first. Antidepressants are the same: they won't stop the bigger fire by themselves, but by preventing you from catching fire right now they give you the tools to deal with the larger problem more effectively that if you tried to do it while flailing around and screaming.
  - john_strinlai 1mo ago
    man, you're all over this submission shitting on antidepressants and questioning people's experiences. it's irresponsible and really not cool.
- sixeyes 1mo ago
  for my snri i lessened the dose by 25% and that alone cost me a week of work, i was so fucked over. when i quit this i will for sure do the thing where you open the capsules and remove a little of the contents, gradually removing more each day. i read online about people doing this and thought they were nutjobs. well, now i know.
ImHereToVote 1mo ago
"People legitimately need these drugs" First. Do no harm.
isolli 1mo ago
Not to mention benzodiazepines... https://www.benzoinfo.com/ https://www.benzoinfo.com/ https://asprescribedfilm.com/ https://asprescribedfilm.com/

Paracompact 1mo ago

> Though this article concentrates on the SSRIs, other meds like the SNRIs can have a similar or even worse withdrawal effect. And don't even get me started on tricyclics or MAOIs... no, seriously, don't get me started on them! The current generation of first-line antidepressants (SSRIs/SNRIs) might as well be free compared to the old school crazy pills.

SV_BubbleTime 1mo ago
> school crazy Yep, that’s how I associate SSRIs.
sheepscreek 1mo ago
Much of medicine (especially mental health related) is rather primitive. We are literally reverse engineering discoveries that seem to work on some other animals, and then figuring out how (to the best of our limited ability). I liken SSRIs to carpet bombing - also their mechanism to increase seratonin in the brain is by making something else not use it (reuptake inhibition). We’re guessing that other thing isn’t a big deal. But who knows. Serotonin is produced in the gut and it controls melatonin, which controls our sleep. It’s all connected in a bizarre way.
- matheusmoreira 1mo ago
  > I liken SSRIs to carpet bombing It's like inserting objects into the body's event loop and hoping it produces the desired effects as it circulates, only to find that everything reacts to the event, not just the parts we want. https://news.ycombinator.com/item?id=37029912 https://news.ycombinator.com/item?id=37029912
KurSix 1mo ago
It's probably less "modern antidepressants are uniquely bad" and more "we got much better at starting people on safer drugs than we did at figuring out how to stop them"

deleted 1mo ago

[deleted]

KurSix 1mo ago

For something prescribed to get someone through a temporary crisis, "how and when do we get you back off this safely?" should probably be discussed at the beginning, not years later when the patient decides to stop.

bcjdjsndon 1mo ago
[flagged]
- probably_wrong 1mo ago
  If a fireman is trying to stop a house fire and suddenly they catch fire themselves, no one would argue that they need to focus on the house fire first. Antidepressants are the same: they won't stop the bigger fire by themselves, but by preventing you from catching fire right now they give you the tools to deal with the larger problem more effectively that if you tried to do it while flailing around and screaming.
- john_strinlai 1mo ago
  man, you're all over this submission shitting on antidepressants and questioning people's experiences. it's irresponsible and really not cool.
sixeyes 1mo ago
for my snri i lessened the dose by 25% and that alone cost me a week of work, i was so fucked over. when i quit this i will for sure do the thing where you open the capsules and remove a little of the contents, gradually removing more each day. i read online about people doing this and thought they were nutjobs. well, now i know.

ImHereToVote 1mo ago

"People legitimately need these drugs" First. Do no harm.

isolli 1mo ago

Not to mention benzodiazepines... https://www.benzoinfo.com/ https://www.benzoinfo.com/ https://asprescribedfilm.com/ https://asprescribedfilm.com/