3 ms·
We can also test for PSEN1, which is 100% accurate in determining early onset alzheimer's disease, quite a it more expensive, so unreasonable as a screening too
by avgDev 1mo ago
We can also test for PSEN1, which is 100% accurate in determining early onset alzheimer's disease, quite a it more expensive, so unreasonable as a screening tool unfortunately.
- brianleb 1mo agoI am skeptical of 100% anything, so did some looking: >>Mutations in PSEN1 and APP are associated with complete penetrance, meaning that all individuals who have a PSEN1 or APP mutation will develop AD if they live a normal lifespan [1] and >>[Age-of-onset] Usually 40s or early 50s (range 30s-early 60s) [2] Note that this is only for early-onset Alzheimer's, representing ~5% of all Alzheimer's. >>Our study showed that the rate of EOAD in AD is 5.5%, not 1-2% as usually demonstrated. And our results indicated that the rate in developed countries was relative higher than in developing countries [3] [1]https://pmc.ncbi.nlm.nih.gov/articles/PMC3326653/ https://pmc.ncbi.nlm.nih.gov/articles/PMC3326653/ [2]https://www.ncbi.nlm.nih.gov/books/NBK1161/table/alzheimer.T.earlyonset_familial_alzheime/ https://www.ncbi.nlm.nih.gov/books/NBK1161/table/alzheimer.T... [3]https://pmc.ncbi.nlm.nih.gov/articles/PMC4356853/ https://pmc.ncbi.nlm.nih.gov/articles/PMC4356853/