3 ms·

From TFA: > Early detection of Alzheimer’s disease is important since the first treatments capable of slowing the progression of the neurodegenerative disease

by gwbas1c 2mo ago

From TFA: > Early detection of Alzheimer’s disease is important since the first treatments capable of slowing the progression of the neurodegenerative disease recently became available to patients, and these drugs are more effective when started sooner rather than later. Other promising investigational drugs are in the pipeline. A very good friend's wife had Alzheimer's caught early, and the medication she's on stopped its progression. It's much better for her than my family members who had no treatment options.

anjel 2mo ago
Creatine supplementation is showing some promising indications of being a low cost, mild to moderate intervention https://www.psychologytoday.com/us/blog/the-modern-brain/202505/new-research-on-creatine-monohydrate-for-alzheimers-disease https://www.psychologytoday.com/us/blog/the-modern-brain/202...
- AppleBananaPie 2mo ago
  Whether this ends up being replicated or not, I love the classic gym bro supplement being studied for its potential benefits to the brain. What a time to be alive
  - Alex3917 2mo ago
    It's going to be replicated because we already know the mechanism of action. That said, many/most people would probably be better off solving the problem more upstream via whatever B-complex vitamins they need based on their bloodwork and DNA methylation variants.
- someothherguyy 2mo ago
  I definitely wouldn't be sharing that as evidence of anything much at all Google scholar link for the article https://scholar.google.com/scholar?cluster=10296105574478709141&hl=en&as_sdt=0,33 https://scholar.google.com/scholar?cluster=10296105574478709...
someothherguyy 2mo ago
> the medication she's on stopped its progression what medication is that?
Palomides 2mo ago
what? there aren't any treatments that stop alzheimers, there are some that help manage symptoms
- derekja 2mo ago
  May not completely stop it, but lecanemab and donanemab are certainly considered to be disease-progression modifying at this point.
amluto 2mo ago
I am not personally aware of any treatment for which there is particularly compelling evidence that it meaningfully slows progression even when started early. I wish there was. It’s also not clear that one can measure progression well enough that an n=1 data point is meaningful. And I’m also far from convinced that very early Alzheimer’s that would progress rapidly enough to be noticeable can be detected with enough specificity to rule out fairly common cases of people who test positive but effectively don’t have the disease. Best wishes to your friend’s wife.
- computerdork 2mo ago
  Agreed that that it’s an interesting question on how to detect Alzheimer’s and also how to treat. My Dad is starting to show signs of mild mental impairment (he’s 87) - more forgetful than usual, more confused than usual, not able to work his computer like he used to… He has taken a personal interest in preventing dementia and wants to take the first generation Alzheimer’s drugs, specifically leqembi that works on amyloid plaques. And this is definitely a tough choice, because eventhough it does show some slowing of the disease, it has lot of side effects that may not be worth it. Personally, I am against it and don’t think it’s worth it as he could do permanent damage to himself. Think he should hang on until the second generation of drugs come out, which should be in the next 1-3 years (there a lot of Alz drugs in the pipeline, but you never know of course if anything will pan out). It’s a tough choice and don’t know if there is a good option at this point.
  - computomatic 2mo ago
    I'm sorry your dad is facing this disease. Hopefully he can find something that helps slow it. I don't know what the side-effects are that he could be facing but, as someone who lost a parent to alzheimers, let me say that anything is probably preferable to advanced-stage dementia. I hope to see real, reliable treatments in my lifetime.
    - computerdork 2mo ago
      Thanks for the info on this. Hmmm, maybe Leqembi isn’t such a bad option. And, would be very surprised if none of the drugs in clinical trials panned out in the next five or six year. It seems like they’re on the verge of making a major breakthrough. Here’s hoping:)
klustregrif 2mo ago
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by gwbas1c 2mo ago

anjel 2mo ago

Creatine supplementation is showing some promising indications of being a low cost, mild to moderate intervention https://www.psychologytoday.com/us/blog/the-modern-brain/202505/new-research-on-creatine-monohydrate-for-alzheimers-disease https://www.psychologytoday.com/us/blog/the-modern-brain/202...

AppleBananaPie 2mo ago
Whether this ends up being replicated or not, I love the classic gym bro supplement being studied for its potential benefits to the brain. What a time to be alive
- Alex3917 2mo ago
  It's going to be replicated because we already know the mechanism of action. That said, many/most people would probably be better off solving the problem more upstream via whatever B-complex vitamins they need based on their bloodwork and DNA methylation variants.
someothherguyy 2mo ago
I definitely wouldn't be sharing that as evidence of anything much at all Google scholar link for the article https://scholar.google.com/scholar?cluster=10296105574478709141&hl=en&as_sdt=0,33 https://scholar.google.com/scholar?cluster=10296105574478709...

someothherguyy 2mo ago

> the medication she's on stopped its progression what medication is that?

Palomides 2mo ago

what? there aren't any treatments that stop alzheimers, there are some that help manage symptoms

derekja 2mo ago
May not completely stop it, but lecanemab and donanemab are certainly considered to be disease-progression modifying at this point.

amluto 2mo ago

I am not personally aware of any treatment for which there is particularly compelling evidence that it meaningfully slows progression even when started early. I wish there was. It’s also not clear that one can measure progression well enough that an n=1 data point is meaningful. And I’m also far from convinced that very early Alzheimer’s that would progress rapidly enough to be noticeable can be detected with enough specificity to rule out fairly common cases of people who test positive but effectively don’t have the disease. Best wishes to your friend’s wife.

computerdork 2mo ago
Agreed that that it’s an interesting question on how to detect Alzheimer’s and also how to treat. My Dad is starting to show signs of mild mental impairment (he’s 87) - more forgetful than usual, more confused than usual, not able to work his computer like he used to… He has taken a personal interest in preventing dementia and wants to take the first generation Alzheimer’s drugs, specifically leqembi that works on amyloid plaques. And this is definitely a tough choice, because eventhough it does show some slowing of the disease, it has lot of side effects that may not be worth it. Personally, I am against it and don’t think it’s worth it as he could do permanent damage to himself. Think he should hang on until the second generation of drugs come out, which should be in the next 1-3 years (there a lot of Alz drugs in the pipeline, but you never know of course if anything will pan out). It’s a tough choice and don’t know if there is a good option at this point.
- computomatic 2mo ago
  I'm sorry your dad is facing this disease. Hopefully he can find something that helps slow it. I don't know what the side-effects are that he could be facing but, as someone who lost a parent to alzheimers, let me say that anything is probably preferable to advanced-stage dementia. I hope to see real, reliable treatments in my lifetime.
  - computerdork 2mo ago
    Thanks for the info on this. Hmmm, maybe Leqembi isn’t such a bad option. And, would be very surprised if none of the drugs in clinical trials panned out in the next five or six year. It seems like they’re on the verge of making a major breakthrough. Here’s hoping:)

klustregrif 2mo ago

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