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It’s in broad terms weight loss related. More specifically blood glucose and insulin regulation which can be out of whack even if you’re not diabetic on paper.
by cloudie78 2mo ago
It’s in broad terms weight loss related. More specifically blood glucose and insulin regulation which can be out of whack even if you’re not diabetic on paper. This is why you’ll see people claiming they’re not diabetic but still saw improvement from Ozempic and friends. Their insulin and glucose regulation was spoke. in casual terms “fucked”.
GLP-1 receptor agonists such as semaglutide act partly through the brain to reduce hunger, increase satiety, and lower spontaneous energy intake. Sustained caloric reduction produces weight loss, including loss of visceral fat around the abdominal organs and ectopic fat stored in tissues such as the liver. These fat depots are metabolically active and contribute to insulin resistance through excess fatty-acid delivery, inflammatory signalling, and disruption of normal insulin action.
As they shrink, muscle and liver tissues become more responsive to insulin, so the pancreas no longer needs to secrete as much insulin to maintain normal glucose levels.
This reduces the compensatory hyperinsulinaemic state that can exist for years before diabetes develops and decreases the probability that impaired glucose regulation will progress toward overt type 2 diabetes.
Those changes propagate into the cardiovascular system.
Better insulin sensitivity and lower visceral and liver fat are commonly accompanied by lower triglycerides, improved blood pressure, reduced systemic inflammation, and better endothelial and vascular function, thereby reducing several mechanisms that contribute to atherosclerosis and cerebrovascular injury.
GLP-1 receptor agonists also have a direct metabolic action independent of weight loss: when glucose is elevated, they enhance pancreatic insulin secretion and suppress inappropriate glucagon secretion, improving glucose control without forcing insulin secretion when glucose is low.
The overall effect is therefore a combination of an immediate GLP-1-mediated improvement in appetite and glucose regulation followed by progressively larger downstream effects from weight and fat loss, which together reduce the metabolic and vascular abnormalities associated with cardiovascular disease and, over much longer periods, potentially with dementia risk.
- jvidalv 2mo ago[flagged]
- acuteaura 2mo agoThere is a fine line between being opposed to fat acceptance and thinking performative cruelty works. (It's does not. It made me so much worse. I have nothing but bad things to say about the medical "professional" who catastrophized my diagnosis to "wake me up" and then shrugged when my response was depressed resignation.)
- owebmaster 2mo agoYou can't depend on people being nice to take care of your own health.
- jnovek 2mo agoThere are several studies now showing that symptoms reported by overweight patients are taken less seriously by medical professionals, it’s not just a matter of people “being nice”. It’s actually providing a lower standard of care.
- owebmaster 2mo agoThere are several studies now showing that recommendations like "losing weight" are taken less seriously by overweight patients.
- acuteaura 2mo agoI should clarify that my doctor explicitly lied to me (found out by requesting my medical file after moving) to shock me on purpose because of his own fifth grade understanding of psychology.
- jnovek 2mo agoWhether patients make good choices is completely independent from whether doctors provide everyone with equal quality of care. Specifically, doctors are less likely to investigate issues that can be explained by obesity than they are in non-fat people. For example, if you have high blood pressure and you are a normal weight your doctor will probably look into underlying conditions that can cause high blood pressure. Being overweight is an independent risk factor for high blood pressure but it doesn’t reduce the likelihood of the other risk factors. Doctors are less likely to look into an underlying cause for high blood pressure if you are overweight.
- abirch 2mo agoJason Fung has preached against modern processed foods that destroy insulin sensitivity. Even artificial sweeteners can raise Insulin levels. His book "The Obesity Code" is a must read and discusses some of the pathways that link insulin and leptin (a hormone associated with eating) TLDR; I'm a Fungster: https://www.youtube.com/channel/UCoyL4iGArWn5Hu0V_sAhK2w https://www.youtube.com/channel/UCoyL4iGArWn5Hu0V_sAhK2w