2 ms·
It's in the article no? > Orexin antagonists (which block the molecules’ actions rather than mimicking it, and thus promote sleep), have been available since 2
by smallnix 2mo ago
It's in the article no?
> Orexin antagonists (which block the molecules’ actions rather than mimicking it, and thus promote sleep), have been available since 2014 as treatments for insomnia. They work differently from conventional sleeping pills, which enhance GABA, one of the brain’s main inhibitory neurotransmitters.
Birgitte Kornum, an expert on orexins at the University of Copenhagen, says such pills induce sedation rather than natural sleep and often lose effectiveness with continued use. Orexin antagonists instead turn down the brain’s wakefulness signal, letting its sleep-promoting systems take over. Evidence suggests this produces better sleep, with less risk of dependence and fewer long-term problems.
- nemomarx 2mo agoThat's just a sleep med, right? I mean something to let you get the repair and cleaning faster, not just induce sleep.
- vrc 2mo agoI’ve used both Belsomra (suvorexant) and Quviviq (daridorexant) and compared to the litany of other sleeping aids, Quviviq in particular is great for me in terms of not being groggy, not knocking me out standing up in case I somehow don’t sleep or need to do something. No rebound on days I run out or if I stop. Feels quite natural—I imagine it feels like what most normal sleepers feel like every evening. It’s nearly impossible for many to get them, tho… Edit: To add some academic merit — there’s been research for its use for cognitive decline [0] [0] https://www.nature.com/articles/s44323-025-00025-5 https://www.nature.com/articles/s44323-025-00025-5