4 ms·

> the real question with Ozempic is.....why are so many bodies not producing enough natural GLP-1 in the first place? Why can’t we synthesize vitamin C? The r

> the real question with Ozempic is.....why are so many bodies not producing enough natural GLP-1 in the first place? Why can’t we synthesize vitamin C? The root-cause solution to vitamin C deficiency is supplementation (through food or otherwise). If our bodies couldn’t figure something like this out, something the rest of the animal kingdom (apart from guinea pigs) did, it strikes me as conceivable is badly optimized in other cases, too.

IncreasePosts 3mo ago
Our bodies did figure it out(our common ancestor with the wet nosed primates could synthesize vitamin C). But our bodies also figured out that for an extended period of time this ability was useless since vitamin C was so readily available in all our food sources in most circumstances.
- JumpCrisscross 3mo ago
  > our bodies also figured out that for an extended period of time this ability was useless since vitamin C was so readily available in all our food sources in most circumstances But none of the other animals in our biomes similarly optimized? Including none of the other apes? The less Panglossian interpretation is a gene got fucked up, it didn't wipe us out, and the fuck-up got conserved because it doesn't kill us before reproduction, it just makes us sicker from time to time.
  - deleted 3mo ago
    [deleted]
  - fragmede 3mo ago
    Fascinatingly, we could biohack our way into having the human liver produce vitamin c, like we have the science to do that. It's just an insane amount of risk compared to just eating an orange once in a while.
  - IncreasePosts 3mo ago
    All apes cannot produce vitamin C. In fact no dry nosed primates can. Also fruit bats generally can't, as well as some passerines, and some bony fish.
    - JumpCrisscross 3mo ago
      > All apes cannot produce vitamin C. In fact no dry nosed primates can You're right! Sorry. And super cool! I'll weaken my hypothesis. There may be a survival advantage in not having to metabolise a vitamin readily available through diet. Altogether, a neutral adaptation/mutation [1]. It's still a good case of nature optimising for leanness like a private-equity boss. And a good example of why something like GLP-1 may have similarly been optimized down for a world no longer relevant. [1] https://pmc.ncbi.nlm.nih.gov/articles/PMC3145266/ https://pmc.ncbi.nlm.nih.gov/articles/PMC3145266/

IncreasePosts 3mo ago

Our bodies did figure it out(our common ancestor with the wet nosed primates could synthesize vitamin C). But our bodies also figured out that for an extended period of time this ability was useless since vitamin C was so readily available in all our food sources in most circumstances.

JumpCrisscross 3mo ago
> our bodies also figured out that for an extended period of time this ability was useless since vitamin C was so readily available in all our food sources in most circumstances But none of the other animals in our biomes similarly optimized? Including none of the other apes? The less Panglossian interpretation is a gene got fucked up, it didn't wipe us out, and the fuck-up got conserved because it doesn't kill us before reproduction, it just makes us sicker from time to time.
- deleted 3mo ago
  [deleted]
- fragmede 3mo ago
  Fascinatingly, we could biohack our way into having the human liver produce vitamin c, like we have the science to do that. It's just an insane amount of risk compared to just eating an orange once in a while.
- IncreasePosts 3mo ago
  All apes cannot produce vitamin C. In fact no dry nosed primates can. Also fruit bats generally can't, as well as some passerines, and some bony fish.
  - JumpCrisscross 3mo ago
    > All apes cannot produce vitamin C. In fact no dry nosed primates can You're right! Sorry. And super cool! I'll weaken my hypothesis. There may be a survival advantage in not having to metabolise a vitamin readily available through diet. Altogether, a neutral adaptation/mutation [1]. It's still a good case of nature optimising for leanness like a private-equity boss. And a good example of why something like GLP-1 may have similarly been optimized down for a world no longer relevant. [1] https://pmc.ncbi.nlm.nih.gov/articles/PMC3145266/ https://pmc.ncbi.nlm.nih.gov/articles/PMC3145266/