3 ms·
Icariin too is a PDE5A inhibitor and a cGMP elevator.[1] The antifungal drugs itraconazole and posaconazole directly have the downstream effect NPC1 inhibition
by OutOfHere 3mo ago
Icariin too is a PDE5A inhibitor and a cGMP elevator.[1]
The antifungal drugs itraconazole and posaconazole directly have the downstream effect NPC1 inhibition followed by a reduction in lysosomal cholesterol accumulation.[2][3]
[1] https://pubmed.ncbi.nlm.nih.gov/17169663/ https://pubmed.ncbi.nlm.nih.gov/17169663/
[2] https://pubmed.ncbi.nlm.nih.gov/31919352/ https://pubmed.ncbi.nlm.nih.gov/31919352/
[3] https://pubmed.ncbi.nlm.nih.gov/40516874/ https://pubmed.ncbi.nlm.nih.gov/40516874/